11 results
Oral anticoagulant dosing and bridging for VTE

- Dr. Joseph Shatzel @Clotmaster 

#VTE #DOAC #Bridging #Dosing #Oral
anticoagulant dosing ... Clotmaster #VTE #DOAC ... Dabigatran #Apixaban #Rivaroxaban ... #Loading #DVT #Pharmacology ... #Hematology
DOAC: Cheat Sheet - Atrial Fibrillation, VTE Prophylaxis, VTE and Renal Dosing

Renal Dosing:
Apixaban (25% renal clearance):
DOAC: Cheat Sheet ... 60kg, CrCl 15-50 Rivaroxaban ... Anticoagulation #Hematology ... #Pharmacology # ... Apixaban #Rivaroxaban
Warfarin to DOAC and DOAC to Warfarin Transitions 

Here are a couple of charts to help
Warfarin to DOAC ... for easier dosing ... Rivaroxaban is < ... Anticoagulation #Pharmacology ... #Table
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓)
of cytochrome p450 CYP3A4 and P-glycoprotein.

DOACs are substrates
) Cancer-treatment ... Rivaroxaban and ... Chemotherapy #Oncology #Hematology ... #Interactions #Table ... #Pharmacology
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis.

Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... , edoxaban and rivaroxaban ... anticoagulants (DOACs ... for appropriate dosing ... Anticoagulation #Management #Hematology
DOAC Reversal
Emergency surgery or urgent procedure
Stop anticoagulant treatment; volume resuscitation and transfusion as needed
Antidotes:
 • Apixaban,
anticoagulant treatment ... Apixaban, Edoxaban or Rivaroxaban ... not available #DOAC ... anticoagulant #hematology ... #management #pharmacology
Xa Inhibitors - Apixaban and Rivaroxaban 
Oral Xa inhibitors are recommended by CHEST as first-line for
- Apixaban and Rivaroxaban ... patients with VTE treatment ... Here is an overview ... of the dosing schemes ... #Dosing #Pharmacology
Perioperative Management of DOACs
Problem:
 ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
clearance (calculated using ... interruption per treatment ... table ... Apixaban, Edoxaban, Rivaroxaban ... #pharmacology #
Managing warfarin INR

Warfarin dosage must be individualized according to the patient's response to the drug, and
#treatment #medications ... #table #pharmacotherapy ... #decisionaid #cardiology ... #hematology #warfarin ... #dosing
Peripartum Cardiomyopathy - Summary
1. Definition
 • Towards the end of pregnancy to 5 months postpartum
Management during ... Avoid Warfarin and DOAC ... Delivery • Stable ... diagnosis #management #cardiology ... #treatment