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management differential arthritis oncology treatment workup joint pain algorithm anemia approach classification gout hemolytic leukemia signs syndrome systemic vasculitis agglutinin
Hemolytic Anemias - Differential Diagnosis Algorithm Signs of anemia and hemolysis: • ↓ Haptoglobin • ↑ LDH
- Differential Diagnosis ... Algorithm Signs ... Hypersplenism, Infection ... Matthew Ho, MD PhD ... #Algorithm #hematology
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
workup for specific symptoms ... organ-specific signs ... or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Illness Script Signs ... and symptoms: ... • Recurrent infections ... Symptomatic anemia Diagnosis ... management #treatment #hematology
Gout (Gouty Arthritis) - MSK Radiology Imaging Findings: • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gouty Arthritis) - MSK ... Radiology Imaging ... mass and NO prior signs ... #diagnosis #msk ... #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
(Cold-induced symptoms ... Diagnosis: • hemolytic ... rewarming • Symptoms ... hemolytic #anemia #hematology ... #diagnosis
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
skin thickening Signs ... and Symptoms: ... lung disease), PAH ... Scleroderma #SSc #rheumatology ... #diagnosis #signs
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Dehydration • Symptoms ... , dyspnea, +/- CXR ... WBC >100k, + lab signs ... Syndrome #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
5 or elevated Cr ... common • Imaging: CXR ... : >3 symptoms, or ... : Infection (sepsis ... #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
: HLH signs and ... symptoms can mimic ... common infections ... Treatment: • Infection ... management #treatment #hematology
Rheumatoid Arthritis Summary Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders Signs & Symptoms:
knees, shoulders Signs ... & Symptoms: • ... : CLINICAL DIAGNOSIS ... corticosteroid injections ... #management #rheumatology
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