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diagnosis differential druginduced lupus management rheumatology comparison dil endocrinology extravascular hemolysis hepatology intravascular lfts liverenzymes pediatrics shortstature sle table thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Inflammatory: • IBD ... effect following treatment ... malignancy • Iron deficiency ... #Causes #Hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Drug-induced AIHA - Abnormal ... • PK deficiency ... perfringens - Complement-Mediated ... #Causes #Hematology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Differential Diagnosis Algorithm ... NAFLD • Others Mild ... • AIH • A1AT deficiency ... disease US — Normal ... #Causes
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... • IGF-I Deficiency ... Panhypopituitarism Treatment ... Celiac, IBD) • ... endocrinology #causes
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
90% - Low complement ... Prognosis: Usually mild ... constitutional symptoms • Treatment ... 80% - Low complement ... life-threatening • Treatment
Drug Induced Lupus (DIL) • Epidemiology: -10% of all lupus cases, drug-dependent, 4:1 to 1:1 F:M
CRP - Usually normal ... 90% - Low complement ... Prognosis: Usually mild ... Discontinuation of causal ... #diagnosis #treatment
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