1147 results
ANCA-Associated Vasculitis
A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated ... - C-ANCA pattern ... antibody) - P-ANCA ... @AnnKumfer #ANCA ... #PANCA #MPO #PR3
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pulmonary Renal ... Presentation (Pulmonary ... Diagnosis for Pulmonary ... testing: anti-ANCA ... @PulmPEEPs #Pulmonary
Rapidly Progressive Glomerulonephritis (RPGN)
RPGN has three primary pathophysiologic causes differentiated by immunofluorescence

Immune Complex Mediated (granular staining):
With associated pulmonary ... Negative IF): • PR3-ANCA ... (C-ANCA): GPA > ... > eGPA • MPO-ANCA ... (P-ANCA): eGPA,
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... Associated - ANCA ... Granulomas - ANCA ... glomerulonephritis and/or pulmonary ... arthritis, obstructive pulmonary
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework
Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis
90%:
 -
Pulmonary Renal ... glomerulonephritis 90%: - ANCA ... Double Positive (ANCA ... Kumfer @AnnKumfer #Pulmonary
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
Antibody) and ANCA ... 80-90%) > MPO - ANCA ... MPO: 75-80% - ANCA ... disease - MPO>PR3 - ANCA ... Antinuclear #Antibody #ANCA
Pulmonary Renal Syndromes - OnePager Summary
Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Pulmonary Renal ... Summary Autoimmune ANCA ... diseases with pulmonary ... Although pulmonary ... Auto-antibodies: ANCA
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis

MPA → usually p-ANCA
GPA → usually c-ANCA
EGPA →
ANCA Associated ... MPA → usually p-ANCA ... EGPA → ANCA in ... 40-50% P-ANCA ... (MPO) C-ANCA (
Approach to managing Glomerulonephritis (GN) in children. 

ANCA, antineutrophil cytoplasmic antibodies; c-ANCA, cytoplasmic antineutrophil cytoplasmic antibodies;
ANCA, antineutrophil ... antibodies; c-ANCA ... hypertension; p-ANCA
Glomerulonephritis - Differential Diagnosis Framework
ANCA:
 • C-ANCA: GPA (Wegener's)
 • P-ANCA: Microscopic Polyangiitis, Eosinophilic GPA (Churg
Diagnosis Framework ANCA ... : • C-ANCA: GPA ... Wegener's) • P-ANCA