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diagnosis differential hematology management rheumatology arthritis algorithm blood chronic joint msk symptoms treatment abdominal abscess approach b12 biliary cardiology chagas
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... - infiltrates (anemia ... #Hematology #Oncology
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Artifact (redo CBC ... Chronic Myelogenous Leukemia ... Infectious: • Acute ... disorders • Celiac disease ... Iron deficiency anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... smear, HIV/HCV testing ... PT, aPTT(liver disease ... changes), high MCV anemia ... #Workup #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Physical Exam/Signs ... • Neutropenia, anemia ... ’s lymphoma or acute ... #diagnosis #workup ... #oncology #hematology
Hematuria Workup and Diagnosis Algorithm • Confirm hematuria → Urinalysis >3 RBCs/HPF, exclude mimics, repeat testing
mimics, repeat testing ... • Acute onset ... unilateral flank pain ... (proteinuria, RBC ... Nephrology if cause
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
intralobular bile ducts causes ... Signs and Symptoms ... Proximal limb muscle wasting ... but elevated as disease ... cholangitis #diagnosis #workup
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
, physical and testing ... potentially be an acute ... dysfunction • PSC ... infarction • Lymphoma/Leukemia ... aneurysms • Acute
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Sweet Syndrome Acute ... with systemic disease ... Episcleritis Signs ... Causes: - Idiopathic ... #dermatology #oncology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... GI - glossitis (pain ... to IBD, celiac disease ... , PBS - anemia, ... diagnosis e.g. leukemia
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... associated with severe pain ... , lasting from 5 ... 2) Aplasia - Acute ... Crisis #Features #Signs
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