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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Microangiopathies In Systemic Lupus ... Erythematosus ... #Erythematosus ... #SLE #hematology ... differential #diagnosis
I’M DAMN SHARP - Lupus Diagnosis Mnemonic
I  	 Immunoglobulins (Anti-dsDNA, Anti-Sm, Anti-phospholipid)
M 	 Malar Rash
D
M DAMN SHARP - Lupus ... D Discoid Rash ... Pleuritis) H Hematologic ... sle #systemic #lupus ... #erythematosus
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... erythematosus ( ... • Nucleolar: Diffuse ... ANA #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Malignancy (e.g. hematologic ... pneumonitis • Diffuse ... enteropathy, and diffuse ... La, anti-Jo-1, SCL
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
Joint Pain Rash ... infection Malar rash ... lesions • Discoid lupus ... erythematosus ... #skin #rashes #differential
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
Pediatrics Patient - Differential ... Suggestive of: Lupus ... Suggestive of: Lupus ... gabrieltalledop #dermatology ... arthritis #skin #differential
An Approach to the Unknown Rash: Erythematous Rash 

#Diagnosis #Dermatology #Erythematous #Rash #Differential #Algorithm #Nikolsky #Sign
to the Unknown Rash ... : Erythematous Rash ... #Diagnosis #Dermatology ... #Erythematous # ... Rash #Differential
Causes of Diffuse Lymphadenopathy - Differential Diagnosis Algorithm
Reactive:
 - Systemic Inflammatory
     •
Causes of Diffuse ... • Systemic Lupus ... Erythematosus ... Hodgkin's Lymphoma #Diffuse ... Algorithm #Causes #Hematology
Hair Loss (Alopecia) - General (Diffuse and Focal) Differential Diagnosis Algorithm

DIFFUSE
Scarring - Irreversible-biopsy required
 • Lupus
and Focal) Differential ... erythematosus ... • Discoid lupus ... erythematosus ... #Differential #
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... 69% - Malar rash ... (aPL) 30-45% Differential ... #Erythematosus ... #rheumatology