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CNS Infection in HIV / AIDS - Differential Diagnosis Framework

Principles of HIV-Associated CNS Opportunistic Infections:
 •
should be based ... on clinical presentation ... Demyelinating disease ... caused by the JC ... InfectiousDiseases #Neurology
Demyelinating Diseases - Differential Diagnosis
 • Inflammatory: MS, ADEM, NMO, Paraneoplastic, Sjogren's, Polyarteritis nodosa, SLE
 •
Demyelinating Diseases ... - Differential Diagnosis ... • Infectious: HIV ... Neurosyphilis, PML ... #causes #neurology
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent
Multiple Ring-Enhancing Lesions:
 • Toxoplasmosis (CD4 < 100)
 • Other
Chorioretinitis • Diagnosis ... PCR 50% sensitive ... #differential #diagnosis ... #causes #radiology ... #neurology
Effects of Strokes by Location - Anterior vs Posterior Localization

Anterior Circulation 
 - MCA 
 -
Territory #Symptoms #Signs ... Localization #Effects #Neurology ... #Diagnosis #Table ... Comprehensive Review in Clinical ... Neurology - https
Bell's Palsy - Diagnosis and Management Summary - GrepMed Handbook

Acute Idiopathic Unilateral Facial Nerve (CN7) Palsy
Presentation:
- Atypical Clinical ... ophthalmoplegia), systemic signs ... endemic area) ± HIV ... inflammatory cause ... Management #Treatment #Neurology
Cytomegalovirus (CMV) in HIV-AIDS Patients
Cytomegalovirus (CMV): double-stranded DNA virus, herpesvirus family.
CMV infection: virus isolation or detection
of symptoms or signs ... PCR and CMV pp65 ... antigenemia test ... 50 or less: • Neurologic ... Retinitis (Most common cause
Romberg's Test for Proprioception
History: First described in the 19th century in patients with tabes dorsalis (later
(Romberg's sign ... Observe when patient closes ... • Cerebellar disease ... Unilateral vestibular disease ... #neurology #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
association • M > F Clinical ... skin injury) • Neurologic ... basal ganglia, CNS ... Behcet syndrome (Clinical ... #management #signs
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis
Baseline Investigations: full blood count with differential,
and Differential Diagnosis ... investigations depending on clinical ... context and signs ... , HIV serology, ... #nephrology #causes
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
and infects the CNS ... Diagnosis: MRI ... Clinical Presentation ... : The clinical ... dementia #AIDS #Neurology