25 results
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... assay (IFA) is the main ... healthy adults, and should ... ANA #patterns #rheumatology ... #diagnosis #differential
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Symptoms of Joint Disease ... categories of joint disease ... both at rest and ... #MSK #rheumatology ... #differential #diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
Positive pathergy test ... is a skin prick test ... Nonsurgical abdominal pain ... #management #signs ... #symptoms #rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... erythematosus (SLE) - Antinuclear ... should be obtained ... , and low back pain ... #testing #Rheumatology
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
in Sickle Cell Disease ... common sites: hip, shoulder ... Osteomyelitis / Septic Arthritis ... #differential #diagnosis ... #causes #hematology
Cold Urticaria
Prevalence - 0.05% in the population
Disease onset - Mostly 2nd to 4th decades of life
Causes
Nausea, abdominal pain ... Disorientation, vertigo Diagnostic ... Cold #Urticaria #diagnosis ... #rheumatology # ... comparison #table
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
Diagnosis Framework ... axial (spine, shoulders ... noninflammatory Signs ... #Diagnosis #MSK ... #rheumatology #
Rheumatoid Arthritis Summary
Overview: chronic, inflammatory symmetric polyarthritis involving small joints of hands/feet, knees, shoulders
Signs & Symptoms:
Rheumatoid Arthritis ... hands/feet, knees, shoulders ... Signs & Symptoms ... inflammatory) • joint pain ... #rheumatology
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
of hip (rare), Arthritis ... lesions Abdominal pain ... (20%) Renal disease ... erythematosus #signs ... #rheumatology
Antinuclear antibodies and Systemic lupus
Anti-dsDNA	60-80%	Association with disease activity (when with Farr assay) and lupus nephritis. Can
Antinuclear antibodies ... clinically suspected, tests ... erythematosus #diagnosis ... #rheumatology # ... table #ANA