21 results
Hemolytic Anemias - Differential Diagnosis Algorithm

Signs of anemia and hemolysis:
 • ↓ Haptoglobin
 • ↑ LDH
Hemolytic Anemias ... Signs of anemia ... Reticulocytes • Abnormal peripheral ... smear Immune-mediated ... Anemias (AIHAs)
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
Megaloblastic Anemia ... anemia (e.g. ... anemia Sickled ... Analysis #hematology #microscopy ... interpretation #clinical #anemia
Laboratory Testing in Hemolytic Anemia

Intravascular vs Extravascular Hemolysis
Reticulocytes
Unconjugated bilirubin
LDH
Peripheral smear
Haptoglobin
Urine hemosiderin
Urine hemoglobin
Carboxyhemoglobin

#Hemolytic #Anemia #Laboratory #Testing #workup
Anemia Intravascular ... Extravascular Hemolysis ... bilirubin LDH Peripheral ... smear Haptoglobin ... #Anemia #Laboratory
Peripheral blood findings in microangiopathic hemolytic anemia.  DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... anemia. ... anemia is characterized ... #anemia #Hematology ... #Microscopy
Here is another peripheral blood smear demonstrating changes with iron deficiency anemia. Note the increased zone
Here is another peripheral ... blood smear demonstrating ... iron deficiency anemia ... #Clinical #Path ... #BloodSmear #Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
Hereditary:
 • Peripheral blood smear + DAT + further History
 •
Hemolytic Anemia ... Hereditary: • Peripheral ... blood smear + DAT ... → Sickle Cell anemia ... anemia (TTP, HUS
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
Spur-Cell Anemia ... smear showed numerous ... anemia that can ... Spur-cell anemia ... #smear
A 37-year-old woman initially presented with pancytopenia and found to have leukopenia (2.1 × 103/μL) with
promyelocytes, anemia ... treatment, her peripheral ... blood smear showed ... #Clinical #Path ... #Microscopy #Auer
Pancytopenia - Differential Diagnosis Algorithm
 • 12-13 g/dL,
 • ANC < 1800/uL,
 • platelet < 150,000/uL

Initial
12-13 g/dL, • ANC ... BMP, uric acid, peripheral ... smear, reticulocyte ... ↑ Destruction (hemolysis ... Matthew Ho, MD PhD
Algorithm for the evaluation of macrocytic anemia. (RBC = red blood cell; MMA = methylmalonic acid.)
Physicians
of macrocytic anemia ... by ordering a peripheral ... smear, a reticulocyte ... elevated, but anemia ... megaloblastic anemia