14 results
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
, CML, AML, APML ... -> AML: Blast crises ... smear: Blasts APML ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... in APML Epidemiology ... Incidence: common in APL ... Infection (sepsis), PE ... #APML #diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
involve one, two, or all ... transformation to AML ... Myelogenous Leukemia (CML ... progression to AML ... #diagnosis #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... phenomenon CLL Diagnosis ... • Richter’s Syndrome ... Transform to DLBCL, PML ... leukemia • Sezary syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Mechanisms: • Direct Damage ... Constitutional Syndromes ... Aplastic Anemia Clinical ... Anemia #oncology #hematology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... signs of end organ damage ... Lysis of tumor cells ... #TLS #diagnosis ... #management #hematology
HIV-Associated Neurocognitive Disorder (HAND)

Definition:
HIV-Associated Neurocognitive disorders categories:
• Asymptomatic neurocognitive impairment
• Mild neurocognitive impairment
• HIV dementia

Pathophysiology:
HIV frequently
is similar to PML ... well-defined than PML ... Diagnosis: MRI ... etiologies and PML ... syndrome of HAD
A quick infographic on the importance of sun protection and the various results of sun damage
wavelengths #causes #diagnosis ... #dermatology #skin ... Toxicol Appl Pharmacol ... non-melanoma skin cancer: clinical ... in skin cells.
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
resulting in end-organ damage ... rapidly progresses: cell ... death Common Clinical ... O2 delivery • PE ... Classification #diagnosis
Shock Overview
A state of tissue hypoxia due to decreased or dysregulated oxygen delivery or extraction, resulting
resulting in end-organ damage ... rapidly progresses: cell ... death Common Clinical ... O2 delivery • PE ... Classification #diagnosis