12 results
Rouleaux formation is common in IgM gammopathy and may be particularly striking

Genevieve Crane, MD, PhD@evemariecrane

#Rouleaux #formation
IgM #gammopathy #MGUS ... #Clinical #Pathology ... #Hematology #Smear
Sickle cell anemia and Howell Jolly bodies (nuclear remnants).

 - Dr. Abubaker Elshaikh
@ElshaikhMD

#SickleCell #HowellJolly #Body #Bodies
#HowellJolly #Body ... #Bodies #Pathology ... #Hematology #Smear ... #Clinical #Microscopy
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
Gammopathy of Clinical ... Significance (MGUS ... Ig deposition disease ... #Significance #MGUS ... Differential #Diagnosis #hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
ULN R - Renal disease ... g/dl LLN B - Bony ... chain deposition disease ... #Gammopathies #MGUS ... #diagnosis #hematology
Plasma cell leukemia with extensive rouleaux formation. Aggressive disease & patients typically younger than other forms
Aggressive disease ... rouleaux #formation #Clinical ... #Smear #Hematology ... #Pathology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison

Hodgkin's Lymphoma:
 • Epidemiology: young adults 20-30, older 50-70
 •
• Clinical features ... portion of the body ... throughout the body ... Noncontiguous spread • Clinical ... #differential #hematology
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
from the normal body ... Diagnosis: • + Clinical ... Biopsy: Typical pathologic ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Disease ... Cold Agglutinin Disease ... Viral Infection Clinical ... significance (MGUS ... hemolytic #anemia #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Significance (MGUS ... vaccinations Renal disease ... Ig deposition disease ... rituximab (in clinical ... Complications #diagnosis #hematology
Myeloma: In this BM core, most plasma cells contain cytoplasmic immunoglobulin (Russell bodies).

They're difficult to identify
RussellBodies #Body ... PlasmaCells #BoneMarrow #Clinical ... #Pathology #Hematology