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rheumatology differential management granulomatosis mpo polyangiitis aav acute associated causes classification eosinophilic glomerulonephritis gpa injury kidney laboratory microscopic mpa nephrology
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
polyangiitis (GPA ... polyangiitis (EGPA ... - C-ANCA pattern ... #CANCA #PANCA # ... MPO #PR3 #Diagnosis
Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021
Polyangiitis (GPA ... Polyangiitis (MPA) - ANCA ... Polyangiitis #MPA #ANCA ... #Treatment #ACR2021 ... #Guidelines #algorithm
Eosinophilic Granulomatosis with Polyangiitis (EGPA) - ANCA Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Active
) - ANCA Vasculitis ... alone in select pts ... #Polyangiitis #ANCA ... #Treatment #ACR2021 ... #Guidelines #algorithm
ANCA Associated Vasculitis (AAV) - Auto-antibodies and Differential Diagnosis MPA → usually p-ANCA GPA → usually c-ANCA EGPA →
and Differential Diagnosis ... GPA → usually ... c-ANCA EGPA → ANCA ... PR3) X-ANCA (elastase ... ANCA Vasculitis
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Negative IF): • PR3 ... -ANCA (C-ANCA): ... GPA >>> MPA > eGPA ... • MPO-ANCA (P-ANCA ... GPA Stanford Internal
Frequency of ANCA Positivity in Different Conditions ANCA-Associated Vasculitis • GPA - PR3-ANCA 75%, MPO-ANCA 20%, 5%
GPA - PR3-ANCA 75% ... • MPA - PR3-ANCA ... • EGPA - PR3- ... - PR3-ANCA 10%, ... #MPO #PR3 #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
proteinase 3 (PR3 ... in >90%, MPO > PR3 ... 60% • GPA: ... 80% (80-90% have PR3 ... (Dx: GPA, EGPA,
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Summary Autoimmune ANCA ... Renal Syndromes (PRS ... defining feature, PRS ... Auto-antibodies: ANCA ... of PRS: Biopsy
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Pre-Renal: • Hypovolemia, Cardiorenal, Distributive Shock, HRS, Hypercalcemia, Renal
Kidney Injury (AKI ... Framework Pre-Renal ... Emboli, Thrombosis, Vasculitis ... • GN: ANCA, Anti-GBM ... nephrology #causes #algorithm
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
proteinase 3 (PR3 ... in > 30 / MPO > PR3 ... hemoptysis, MPO > PR3 ... 60/ GPA (Granulomatosis ... 90 percent have PR3
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