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Gitelman Syndrome Overview What? • Inherited (AR) hypokalemic salt-losing tubulopathies affecting the thiazide-sensitive sodium chloride cotransporter • Gitelman's syndrome
Family history of hypokalemia ... • Unexplained hypokalemia ... pressure Labs: • Hypokalemia ... ratio 0.5%) Differential ... #Hypokalemia
Causes of HyperKalemia - Differential Diagnosis Increased extracellular K+: • Tissue injury • Hemolysis • Rhabdomyolysis •
Causes of HyperKalemia ... - Differential ... Hemolysis • Rhabdomyolysis ... blockers - MCW Nephrology ... MCW_Nephrology #HyperKalemia
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome ... Pathophysiology ... H+ secretion → Hypokalemia ... #Syndrome #Pathophysiology ... #nephrology #diagnosis
Hypokalemia - Differential Diagnosis Algorithm Extra-renal Losses: • Normal Acid-Base: Low intake • Metabolic acidosis: Gl tract
Hypokalemia - Differential ... Bartter syndrome, Gitelman ... @priti899 #Hypokalemia ... #Differential # ... potassium #low #nephrology
Hypokalemia Evaluation Algorithm Before evaluating hypokalemia, life threatening complications such as arrhythmias and paralysis should be looked
Hypokalemia Evaluation ... Before evaluating hypokalemia ... in evaluating hypokalemia ... differentiating kidney ... @krithicism #Hypokalemia
Algorithm for patients with hypokalemia on the basis of the potassium-to-creatinine ratio in the urine Urine K+
patients with hypokalemia ... ↑ Aldosterone: Kidney ... Bartter syndrome, Gitelman ... syndrome #hypokalemia ... urine #potassium #differential
Causes of Hypokalemia - Differential Diagnosis Algorithm Defining the cause of hypokalemia starts by measuring urinary K
Causes of Hypokalemia ... Defining the cause of hypokalemia ... Hypomagnesemia-induced hypokalemia ... Bartter's syndrome, Gitelman's ... Cushing's syndrome #hypokalemia
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Differential Diagnosis ... • LDH ↑ • Hyperkalemia ... nephrotoxicity to kidney ... Dialysis for severe hyperkalemia ... causes #treatment #nephrology
Hypokalemia Differential Diagnosis Algorithm Hypertensive: • High Al, Low R - Primary aldosteronism • High Al, High
Hypokalemia Differential ... Bartter's syndrome, Gitelman's ... syndrome #Hypokalemia ... #Differential # ... Diagnosis #Algorithm #nephrology
Hypomagnesemia - Differential Diagnosis Renal Causes of Hypomagnesemia - Familial: Bartter syndrome and Gitelman syndrome, Isolated recessive hypomagnesemia,
Hypomagnesemia - Differential ... Bartter syndrome and Gitelman ... with secondary, hypocalcemia ... pentamidine), Hypercalcemia ... diagnosis #causes #nephrology
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