22 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Disease: Primary Biliary ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... Drugs - Primary biliary ... - Other biliary ... Diagnosis #Algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Pathophysiology ... cholestasis → Cirrhosis/Liver ... Labs: • Alkaline ... or higher • Liver ... diagnosis #workup #hepatology
Liver Function Test (LFTs) Elevation
AST - Cardiac and skeletal muscle, kidney, brain
ALT - More specific for
Liver Function Test ... ALP - Biliary ... Transaminase >> Alkaline ... Cholestatic Pattern - Alkaline ... Transaminitis #diagnosis #hepatology
Liver Function Tests (LFTs) - Normal Values and Interpretation

Alanine aminotransferase (ALT/SGPT) - Liver, cardiac & skeletal
Interpretation Alanine ... , lungs, RBCs Alkaline ... , biliary epithelium ... Conjugated/DBili) - Biliary ... Interpretation #diagnosis #hepatology
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
hepatitis, Acute biliary ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Extrahepatic • Biliary ... Acute #algorithm #hepatology
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Primary Biliary ... Cirrhosis - Pathophysiology ... relative with PBC ... Pathophysiology ... #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary ... Liver biopsy findings ... #PBC #Primary ... #Biliary #Cirrhosis ... Diagnosis #Algorithm #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... , PSC, Alcoholic ... - CBD stone, Biliary ... stricture, PSC, ... Algorithm #diagnosis #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
, PSC, IgG4, HLH ... Extrahepatic - Biliary ... Choledocholithiasis, Biliary ... - Obstruction: Biliary ... diagnosis #algorithm #hepatology