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hematology oncology differential bloodsmear causes hemolytic leukemia management microscopy workup chronic cll lymphocytic path pathology agglutinin algorithm analysis aplastic asplenia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Sickled red cells ... : Sickle cell disease ... #Blood #Smear # ... interpretation #clinical
Hemolytic Anemia - Differential Diagnosis Algorithm Hereditary: • Peripheral blood smear + DAT + further History •
- Differential Diagnosis ... Hereditary: • Peripheral ... blood smear + DAT ... Deficiency • Sickle ... → Sickle Cell anemia
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... DIC is a clinical ... and laboratory diagnosis ... smear changes are ... #Hematology #Pathology
Sickle cells These photos show sickle cells on peripheral blood smears. In the left photo target cells
cells on peripheral ... blood smears. ... clinically and ... no significant anemia ... #Clinical #Path
Spur-Cell Anemia- A 31-year-old man with a history of cirrhosis, recurrent hepatic encephalopathy, and anemia presented
Spur-Cell Anemia ... confusion...A peripheral-blood ... anemia, a form ... #NEJM #clinical ... #peripheral #blood
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
blood smear or ... - infiltrates (anemia ... • Peripheral smear ... more aggressive form ... #Oncology #Diagnosis
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemoglobin Defects: Sickle ... cell anemia, Thalassemias ... Dehydrogenase ↑ - Peripheral ... Blood Smear ↑ abnormal ... #hematology
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
cell count (anemia ... Smear: • Dysplastic ... blood smear • ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
released in the peripheral ... defects (e.g. sickle ... cell anemia, G6PD ... Production #Index #hematology ... #diagnosis #calculation
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Orange or Hep C Clinical ... cytometry • Peripheral ... smear: Smudge cells ... Lymphocytosis: Absolute blood ... • Neutropenia, anemia
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