26 results
Autoimmune Hemolytic Anemia (AIHA) - Differential Diagnosis Table

Warm AIHA (48-70%)
Cold AHA (16-32%)
 • Donath-Landsteiner HA (paroxysmal
Autoimmune Hemolytic Anemia ... Diagnosis Table ... Autoimmune #Hemolytic #Anemia ... #Diagnosis #Table ... #hematology
Autoimmune Hemolytic Anemia (AIHA) Treatment
Warm AIHA:
1) Steroids - 1-2 mg/kg prednisone daily
   • Until
Autoimmune Hemolytic Anemia ... (AIHA) Treatment ... underlying condition • Monoclonal ... Autoimmune #Hemolytic #Anemia ... #management #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
• Neutropenia, anemia ... thrombocytopenia • AIHA ... Hypogammaglobulinemia • Warm AIHA ... Leukemia #diagnosis #workup ... #oncology #hematology
Hemolysis - Diagnostic Algorithm and Causes

Increased red cell production: 
 • Increased Reticulocytosis/polychromasia 
 • Erythroid
Increased red cell ... Increased red cell ... Hemolysis #Hemolytic #Anemia ... Differential #Causes #Workup ... #Hematology #Diagnosis
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
women • 15% of AIHA ... • Symptoms of anemia ... • hemolytic anemia ... malignancies - B-cell ... #hematology #diagnosis
Chronic Lymphocytic Leukemia (CLL) - Summary
Overview: 
 • Most common leukemia in adults
 • Disorder of
lymphocytes, smudge cells ... 5) Symptoms of anemia ... cytopenias (ITP, AIHA ... AIHA, PRCA) • Treatment ... fludarabine) 3) Monoclonal
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm
Extravascular - Spleen and RES-mediated hemolysis
 -
• Cold AIHA ... • Drug-induced AIHA ... • Sickle cell ... immune-complex hemolytic anemia ... Algorithm #Causes #Hematology
Monoclonal Gammopathy of Undetermined Significance (MGUS) - Summary Framework

Hematologic disorder characterized by the presence of either
No evidence of anemia ... marrow plasma cells ... insufficiency, Anemia ... to the plasma cell ... #Significance #hematology
Blood Disorders - Markers and Differential Diagnosis Algorithm 
Acute
 • Myloid (AML) - CD13, CD33, CD34,
CD10 - T-cell ... Pelger-Huet, Macrocytic anemia ... o CML - bcr-able ... o Other bcr-able ... Blood #Disorders #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Microangiopathic hemolytic anemia ... - Autoimmune (AIHA ... - Autoimmune (AIHA ... Hemoglobinopathies (e.g. sickle cell ... #anemia