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diagnosis hematology management chronic cll lymphocytic syndrome anemia aplastic apml causes coagulation differentiation disseminated intravascular mds myelodysplastic workup
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
Acute leukemias ... ALL (Acute Lymphoblastic ... Blasts APML (Acute ... Fibrinolysis & DIC ... #Hematology #Oncology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
microglobulin Treatment ... ’s lymphoma or acute ... leukemia #CLL ... diagnosis #workup #oncology ... #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
Chronic Lymphocytic Leukemia ... • Most common leukemia ... Transformation to large cell ... #oncology #hematology ... #hemeonc #diagnosis
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
= funny-shaped cells ... transformation to acute ... leukemia Management ... Allogeneic stem cell ... #hematology #oncology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
malignancy (Especially acute ... promyelocytic leukemia ... Schistocytes, helmet cells ... + Bleeding Treatment ... diagnosis #causes #treatment
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Triggers: ATRA treatment ... Release from blast cells ... • Induce blast cell ... fluid overload, PCC ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
virus (EBV) • Leukemia ... • ↓ WBC • ↓ PLT ... aplastic anemia Treatment ... Aplastic #Anemia #oncology ... #hematology #diagnosis
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