13 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... - Infection (EBV ... CMV), Alcoholic cirrhosis ... #Injury #hepatology ... #LFTs #transaminitis
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Differential Diagnosis Algorithm ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Bile Ducts • PSC ... • Alcoholic hepatitis ... Infiltrative • Cirrhosis ... • Others #LFTs
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
C, A, E, B, D, EBV ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Causes #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... HBV, HCV, HEV, EBV ... function may be abnormal ... : < 1 • Cirrhosis ... #hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
/Liver failure ... or higher • Liver ... Diagnosis: • Viral hepatitis ... #diagnosis #workup ... #hepatology
The Liver Consult Primer - Guide to calling a consult
HPI:
 - Start with reason for consult
Gl History - Cirrhosis ... - Vitals - LFTs ... , plt, INR, GTT, ... disease work up ... Calling #Referral #Hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework:
Liver Injury → liver test abnormalities without evidence of liver
• Infections: Hepatitis ... A/B/C/D/E, EBV, ... Differential #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... Check Acute viral hepatitis ... : < 1 • Cirrhosis ... #differential #Hepatology ... transaminitis #LFTs
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
SLE, autoimmune hepatitis ... Dermatomyositis Anti-LKM (liver ... Primary biliary cirrhosis ... (PBC) Anticentromere ... Celiac disease Anti-GBM