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diagnosis biliary cirrhosis hepatology management pbc algorithm antibodies apml associations autoantibodies autoimmune differential differentiation diseases erythematosus hematology lupus myopathy myositis
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... pregnancy Diagnose PBC ... if 2/3 criteria ... consistent with PBC ... #PBC #Primary
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
, Anti-gp210 - Primary ... biliary cirrhosis (PBC ... - Vasculitis, e.g ... - Vasculitis, e.g ... diagnosis #table #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Prednisone 5mg/kg ... Infection (sepsis), PE ... fluid overload, PCC ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... • Malignancy (e.g ... the context of primary ... Antiribosomal P, APLA, PAC ... Erythematosus #Diagnosis #Rheumatology
Primary Biliary Cirrhosis - Management A. Initiate therapy - Initiate 1st line therapy with UDCA (13-15
Primary Biliary ... UDCA (13-15 mg/kg ... /or prognostic criteria ... survey disease #PBC ... #Primary #Biliary
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Aldolase levels • EMG ... RP-ILD), dermato-rheumatologic ... muscle weakness PE ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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