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differential transaminitis hepatitis causes dili gastroenterology hbv treatment aclf aflp aih autoimmune chemistry cirrhosis drug druginduced failure fatty function hepatocellular
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Tests (LFTs) - ... Cirrhosis • Chronic ... Hepatopathy • Acute ... injury) • Ischemic ... #hepatology #transaminitis
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... 5-10x normal - Chronic ... #Injury #hepatology ... #LFTs #transaminitis ... #differential #diagnosis
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... Diagnosis Hepatocellular ... #Diagnosis #Causes ... #Acute #algorithm ... #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... - Differential Diagnosis ... Algorithm Vascular ... #injury #hepatitis ... #algorithm #hepatology
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... Injury (DILI) ... #Chronic #Liver ... Failure #Cirrhosis #Hepatology ... #diagnosis
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... presentation • Chronic ... - ongoing ↑ LFTs ... #algorithm #gastroenterology ... #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
: Liver Injury ... Infections: Hepatitis ... #Diagnosis #hepatology ... #algorithm #Transaminitis ... #LFTs #hepatitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
Interpretation of LFTs ... > 3 • Chronic ... #chemistry #diagnosis ... #differential #Hepatology ... transaminitis #LFTs
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Stepwise Diagnosis ... Algorithm DILI ... dechallenge • Acute ... #Injury #Diagnosis ... #Algorithm #hepatology
Chronic Hepatitis B - Diagnosis and Management Algorithm • Who to treat: Essentially treat the pts with
Chronic Hepatitis ... Management Algorithm ... Chronic Hepatitis ... #Algorithm #Diagnosis ... #Hepatology
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