7 results
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Pathophysiology ... • Induce blast cell ... Prednisone 5mg/kg ... #diagnosis #management ... #hematology #oncology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Cytopenia +++ (Plt ... Lymphohistiocytosis #diagnosis #management ... #rheumatology
IgG4-Related Disease
Clinical history:  Man, 60 years, multiorgan involvement, unique or multiple inflammatory pseudotumor
4 phenotypes:
 •
Related Disease Clinical ... increased IgG4+ cells ... Disease #diagnosis #management ... #phenotypes #workup ... #treatment #rheumatology
Disseminated Intravascular Coagulation (DIC) Overview

Increased Clotting and Consumption of Clotting Factors

Findings:
 • Bleeding
 • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... Schistocytes, helmet cells ... + Bleeding Treatment ... #management #hematology
Intraoperative  Bradycardia - Guidelines for Crises in Anaesthesia
Bradycardia in theatre should not be treated as
remember to tailor treatment ... reservoir bag and APL ... known drug causes (eg ... Checklist #Diagnosis #Management ... #Workup #Cardiology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... HLH is a critical ... Clinical Presentation ... Pathophysiology ... #Hematology #HemeOnc
Solitary Cell Plasmacytoma

What?
• Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma)
• In 3%
plasmacytoma) Clinical ... red bone marrow, e.g ... Bone marrow Treatment ... Oncology #Diagnosis #Workup ... #Hematology