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hepatology algorithm hematology liver ana antibody antinuclear injury nuclear oncology patterns testing acute anatomical anemia antibodies aplastic arrhythmias associations autoantibodies
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... obstruction, HELLP Syndrome ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... #Diagnosis #Causes
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Diagnosis Algorithm ... Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
Diagnosis Algorithm ... • Pregnancy - AFLP ... Bile Ducts • PSC ... • Alcoholic hepatitis ... #Causes
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... intralobular bile ducts causes ... obstruction • ALP ... bile ducts Differential ... Viral hepatitis,
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
SLE, autoimmune hepatitis ... ) - Autoimmune hepatitis ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... initiation • Differential ... fluid overload, PCC ... #APML #diagnosis ... #management #hematology
Hyperviscosity Syndrome - Causes and Treatment - Waldenstrom macroglobulinemia (most common) / Plasmapheresis - Multiple
hyperleukocytosis (AML ... - MH/CCF/CWRU EM ... #Causes #Differential ... #Diagnosis #Treatment ... #Management
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
of Pregnancy (AFLP ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Hepatitis, Preeclampsia
Anatomical Differential Diagnosis for Arrhythmias • SA node: Sinus bradycardia, Sick Sinus Syndrome (SSS) • AV
Anatomical Differential ... bradycardia, Sick Sinus Syndrome ... Atrial Flutter (AFL ... Contractions (PVC ... #Diagnosis #Causes
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