17 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
, PBC/SSc OS, PBC ... OSs, cerebellar ataxia ... ARUPConsult @ARUPLabs #ANA ... #differential #diagnosis ... #rheumatology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... fluid overload, PCC ... Differentiation #Syndrome ... #APML #diagnosis ... #management #hematology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... Immune Aplastic Anemia ... petechiae Causes ... #diagnosis #management
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary
myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... and Management ... old, ~10,000 new cases ... cytopenias (usually anemia ... #hematology #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL

Acute leukemias > 20% blasts in the peripheral blood smear
: Blast crises ... develop leukostasis syndrome ... - infiltrates (anemia ... • Tumor lysis syndrome ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
blood cell count (anemia ... Anemia • Bone ... Megaloblastic Anemia ... Myelophthisic Anemia ... #diagnosis #hematology
Alexia Without Agraphia
Alexia without agraphia is a disconnection syndrome where patients cannot read but can write.
Alexia Without Agraphia ... Alexia without ... disconnection syndrome ... is being read (alexia ... MoiseyWoisey #Alexia
Visceral Leishmaniasis - Diagnosis and Management Summary
Species: Leishmania donovani, Leishmania infantum, Leishmania chagasi
Where: South Asia, East
and Management ... Weight Loss • Can cause ... Lymphohistiocytosis • Anemia ... 20 mg/kg/d IV/IM ... #management #treatment
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Organomegaly+↑RBC/plt ... WAIHA • CAD • PCH ... (-) hemolytic anemia ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
changes (POEMS syndrome ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... Thalassemia, Sickle cell anemia ... #differential #diagnosis