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differential oncology sle erythematosus systemic anemia antibodies aplastic apml associations autoantibodies autoimmune bloodsmear borrelia cerebritis clinical cns comparison differentiation diseases
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
biliary cirrhosis (PBC ... La) - Sjogren's syndrome ... Goodpasture's syndrome ... Associations #diseases #diagnosis ... #table #rheumatology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Demyelinating Syndrome ... autoantibodies that will cause ... permeability Diagnosis ... CNS #neurology #rheumatology ... #management #treatment
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Non-autoimmune rheumatologic ... Antiribosomal P, APLA, PAC ... Erythematosus #Diagnosis ... #Rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Usual therapeutic management ... sle #comparison #table ... #rheumatology # ... diagnosis #management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... fluid overload, PCC ... Differentiation #Syndrome ... #APML #diagnosis ... #management #hematology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Organomegaly+↑RBC/plt ... WAIHA • CAD • PCH ... to cold IgG • Lupus ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
changes (POEMS syndrome ... autoimmune hepatitis, PBC ... , PSC, Viral hepatitis ... gastric tumors • Hematology ... #hematology
Borrelia recurrentis on Peripheral Blood Smear 23M Somali refugee recently arrived w/severe abd pain, confusion and fever
12.5, WBC 14, Plt ... Syndrome: 3d of ... The table below ... LBRF can be diagnosed ... or PenG 800K U IM
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... and petechiae Causes ... • ↓ WBC • ↓ PLT ... Anemia #oncology #hematology ... #diagnosis #management
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... RP-ILD), dermato-rheumatologic ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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