13 results
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns
Nuclear Patterns:
 • Homogeneous pattern: 
   -
• Reticular/AMA ... , PBC/SSc OS, PBC ... /SjS OS - AMA ... body-like: - Neurologic ... Cytoplasmic #Patterns #differential
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
intralobular bile ducts causes ... progresses • +AMA ... patients • +ANA ... 1.5 x ULN • AMA ... bile ducts Differential
Antinuclear Antibody Testing Cytoplasmic Patterns
Reticular/AMA: 
 • PBC, SSc, PBC/SSc OS, PBC/SjS OS
 • AMA
Speckled:
 •
Patterns Reticular/AMA ... PBC/SSc OS, PBC/ ... SjS OS • AMA Speckled ... body-like: • Neurologic ... ARUPConsult @ARUPLabs #ANA
Acute Altered Mental Status - Rapid Response Management

1) Ask while en route: vitals, hyper/hypoactive, POC glucose,
hyper/hypoactive, POC ... Workup 5) Treat ... the underlying cause ... #criticalcare # ... encephalopathy #differential
Recommended initial testing for patients being evaluated for glomerular disease 

24-hour urine collection - Quantify proteinuria.
Spot PC (protein ... antigen, hepatitis C antibody ... infections are common causes ... ANA - Screen for ... glomerular #testing #workup
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
Causes of Lactate ... Lactic Acidosis - Differential ... www.ncbi.nlm.nih.gov/pmc ... / hypoxemia -> focus ... Acidosis #Elevation #Differential
Recommended initial testing for patients being evaluated for glomerular disease
1) 24-hour urine collection - Quantify proteinuria.
Spot PC (protein ... antigen, hepatitis C antibody ... infections are common causes ... glomerular disease. 8) ANA ... glomerular #disease #workup
Transverse Myelitis Overview

Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
• Infectious causes ... sclerosis, NMOSD, MOG antibody ... glycoprotein (MOG) antibody ... Myelitis #diagnosis #management ... #neurology #differential
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Management - GrepMed ... Antibiotics (Bactrim, PCN ... reabsorption) Workup ... only if no clear cause ... Treatment #potassium #nephrology
Dysphagia - Differential Diagnosis Framework

Symptom | Diagnosis
• Solid-food dysphagia present for months to years | Mechanical
Dysphagia - Differential ... • Muscular or neurologic ... disorder URGENT WORKUP ... the underlying cause ... #Diagnosis #Management