12 results
diagnosis differential antibody antinuclear nuclear patterns anemia aplastic apml biliary cholangitis cirrhosis classification cytoplasmic differentiation disorders gap globulin hemophagocytic hepatology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... pattern: - PBC ... : - PBC, SSc ... , PBC/SSc OS, PBC ... differential #diagnosis #rheumatology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Workup History ... smear, HIV/HCV testing ... function test, ANA ... or if a primary hematologic ... #Workup #hematology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
) - Summary PBC ... intralobular bile ducts causes ... patients • +ANA ... cholangitis #diagnosis #workup ... #hepatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... pericarditis • Hepatic: PBC ... Scleroderma #SSc #rheumatology ... signs #symptoms #testing ... #workup
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Albumin > 4) Work-up ... hepatitis, PBC, ... PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
cell adhesion and ... : leukocytosis and ... fluid overload, PCC ... APML #diagnosis #management ... #hematology #oncology
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody Testing ... pattern: • SSc, PBC ... dots pattern: • PBC ... Antinuclear #Antibody #Testing ... differential #diagnosis #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... solid cancers • Autoimmune ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Immunosuppression • Autoimmune ... Hodgkin Lymphoma Workup ... classification #hematology ... #oncology #management
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