25 results
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Acute #algorithm #hepatology
Causes of Fat Malabsorption - Differential Diagnosis
Biliary Duct Obstruction
 • Autoimmune— PBC, PSC
 • Infection— liver
Causes of Fat Malabsorption ... Obstruction • Autoimmune ... — PBC, PSC • Infection ... — liver fluke, HIV ... Differential #Diagnosis #Causes
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
of associated autoimmune ... pregnancy Diagnose PBC ... Liver biopsy findings ... consistent with PBC ... #PBC #Primary
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... : Autoimmune hepatitis ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm

ALP:
 - Enzymes that catalyze hydrolysis of organic phosphate
disturbance (obstructed liver ... Highest • Bone • Liver ... Intestine - Other causes ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... • Ischemia • Autoimmune ... Bile Ducts • PSC ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
indications for liver ... and end-stage liver ... disease management ... Cholangitis #diagnosis #management ... #summary #Hepatology
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
) - Summary PBC ... 30-65 years PBC ... intralobular bile ducts causes ... cholestasis → Cirrhosis/Liver ... or higher • Liver
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
Autoimmune Hepatitis ... disease to acute liver ... hepatocellular pattern of liver ... reported (eg AIH-PBC ... #Hepatology
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
common in SLE, autoimmune ... Dermatomyositis Anti-LKM (liver ... microsomal) - Autoimmune ... biliary cirrhosis (PBC ... diagnosis #table #rheumatology