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diagnosis differential hepatology algorithm rheumatology ana antibody antinuclear hepatitis injury liver nuclear testing acute aih cholangitis cytoplasmic differentiation lfts liverenzymes
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
: - SSc, PBC/ ... : - PBC, DM, ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... SjS, SLE, RA, PBC
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... hepatitis, Acute biliary ... Malignancy, 1° PBC ... , 1° PSC, Cystic
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... : Autoimmune hepatitis ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
) PSC is a chronic ... • COVERT - PSC ... patients with PSC ... pathogenesis of PSC ... • CANCER - PSC
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Scl70 (in some cases ... : • SSc, PBC/SSc ... : • PBC, DM, other ... conditions • Sp-100, PML ... differential #diagnosis #rheumatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
• Ischemia • Autoimmune ... Bile Ducts • PSC ... Duct Stone • Biliary ... Others #LFTs #Hepatology ... Diagnosis #Algorithm #Causes
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome in APML ... fluid overload, PCC ... Differentiation #Syndrome #APML ... #diagnosis #management ... #hematology #oncology
Autoimmune Hepatitis Clinical Presentation - Highly variable clinical presentation, from subclinical disease to acute liver failure. -
Autoimmune Hepatitis ... hepatocellular pattern ... though cholestatic pattern ... reported (eg AIH-PBC ... #Hepatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... slow onset and pattern ... statins - probably caused ... Other Diseases: • PBC ... Myositis #Myopathy #rheumatology
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