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differential hepatology rheumatology algorithm cholangitis testing treatment ana antibody antinuclear biliary cirrhosis gastroenterology hemophagocytic hepatitis hlh injury liver lymphohistiocytosis nuclear
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... PBC if 2/3 criteria ... consistent with PBC ... #PBC #Primary ... #Algorithm #hepatology
Primary sclerosing cholangitis (PSC) - Malignancy Screening and Surveillance Recommendations Cholangiocarcinoma - Annual US or
Primary sclerosing ... cholangitis (PSC ... #cholangitis #PSC ... #Malignancy #Cancer ... Gastroenterology #Management
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... Other: NAFLD, Autoimmune ... Malignancy, 1° PBC ... , 1° PSC, Cystic ... Pancreatic Pseudocyst, Cancer
The 6 C’s of Primary Sclerosing Cholangitis (PSC) PSC is a chronic, cholestatic, immune-mediated disease characterized by
) PSC is a chronic ... • COVERT - PSC ... patients with PSC ... pathogenesis of PSC ... • CANCER - PSC
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Cirrhosis (PBC) ... - Summary PBC ... 30-65 years PBC ... Liver failure PBC ... • Fatigue PBC
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
pattern: - SSc, PBC ... pattern: - PBC ... , SSc, PBC/SSc OS ... , PBC/SjS OS ... SjS, SLE, RA, PBC
Alkaline Phosphatase (ALP) Elevation - Differential Diagnosis Algorithm ALP: - Enzymes that catalyze hydrolysis of organic phosphate
- Differential Diagnosis ... Intestine - Other causes ... - Drugs - Primary ... biliary Cholangitis (PBC ... Infiltrative diseases - PSC
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... Algorithm Vascular Causes ... , PBC, PSC, IgG4 ... stone, Malignancy, PBC ... , PSC, Cystic fibrosis
Elevated Liver Enzymes - Differential Diagnosis Algorithm Severe ALT > 15x ULN • Viral • Drugs/Toxins •
- Differential Diagnosis ... • Ischemia • Autoimmune ... Bile Ducts • PSC ... • Pancreatic cancer ... #Algorithm #Causes
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... , Anti-gp210 - Primary ... biliary cirrhosis (PBC ... Associations #diseases #diagnosis ... #table #rheumatology
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