14 results
diagnosis hemophagocytic hlh lymphohistiocytosis treatment differential syndrome systemic anemia antibodies aplastic apml associations autoantibodies classification coagulation dic differentiation diseases disseminated
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
common in SLE, autoimmune ... microsomal) - Autoimmune ... , Anti-gp210 - Primary ... biliary cirrhosis (PBC ... diagnosis #table #rheumatology
Systemic Sclerosis (Scleroderma) Multi-system autoimmune disease characterized by vasculopathy and progressive fibrosis of skin and internal organs 3
Multi-system autoimmune ... pericarditis • Hepatic: PBC ... (primary biliary ... Scleroderma #SSc #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Cytopenia +++ (Plt ... assessment+++ Primary ... solid cancers • Autoimmune ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
fluid overload, PCC ... APML #diagnosis #management ... #hematology #oncology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Cirrhosis, ETOH, autoimmune ... hepatitis, PBC, ... PSC, Viral hepatitis ... gastric tumors • Hematology ... differential #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Treatment: • Treat primary ... cause • Correct ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
disease • Non-autoimmune ... rheumatologic diseases ... the context of primary ... Antiribosomal P, APLA, PAC ... Erythematosus #Diagnosis #Rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count • ↓Hg & PLT ... + distinctive primary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • ↓ WBC • ↓ PLT ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
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