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Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Platelet Disorders - Differential ... smear, HIV/HCV testing ... K), H. pylori test ... thyroid function test ... #Workup #hematology
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody Testing ... Scl70 (in some cases ... Antinuclear #Antibody #Testing ... Cytoplasmic #Patterns #differential ... #diagnosis #rheumatology
Torsades de Pointes (TdP): Pathogenesis and Clinical Findings Polymorphic ventricular tachycardia initiated by PVC in the setting
Pathogenesis and Clinical ... in the setting ... TdP #Diagnosis #pathophysiology ... #cardiology #causes ... #differential
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Pathophysiology ... intralobular bile ducts causes ... Proximal limb muscle wasting ... bile ducts Differential ... diagnosis #workup #hepatology
Heparin Induced Thrombocytopenia (HIT) - Diagnosis and Management - GrepMed Handbook Presentation: • Plts ↓50% (nadir
♀, ↑Age, ESRD Pathophysiology ... Diagnosis: • Clinical ... approach for post-test ... : Confirmatory test ... Management #Treatment #Hematology
Acute Fatty Liver of Pregnancy (AFLP) Pathophysiology: • Defect in fetal free fatty acid metabolism products →
Pregnancy (AFLP) Pathophysiology ... = nonspecific (nausea ... Cr, ↓Glucose, ↓PLT ... infiltration) Differential ... Maternal Support - Critical
D-dimer Plasma D-dimer is a product of clot breakdown, released upon degradation of polymerized, crosslinked fibrin. Elevated
age, which can cause ... false positive tests ... adjusted d-dimer testing ... Ddimer #dimer #pathophysiology ... #hematology #differential
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
protein C and S Pathophysiology ... organ damage Clinical ... Treat primary cause ... Coagulation #diagnosis #causes ... treatment #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... accumulation of clinical ... Cytopenia +++ (Plt ... Drugs, Unknown cause ... treatment #summary #rheumatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... Positive Coombs testing ... younger pts) Differential ... • Diagnostic Test ... hemolytic #anemia #hematology
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