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diagnosis differential intravascular erythematosus hemolysis management sle systemic treatment anemia atlas basics cerebritis child cns coagulation dermatology dic disseminated glomerulonephritis
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... usually IgM) (e.g. primary ... #diagnosis #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... • PCH • PNH ... Differential #Diagnosis #Algorithm ... #Causes #Hematology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
RPGN has three primary ... pathophysiologic causes ... Post-strep GN, Lupus ... differential #diagnosis #algorithm ... #rheumatology
Hyponatremia - Differential Diagnosis Algorithm Hypovolemic - Give volume Hypervolemic (Edematous) - Look for and treat underlying cause
treat underlying cause ... Solute Intake - Primary ... Pulmonary Diseases, CNS ... Disease, Meds ( ... #diagnosis #nephrology
THE LIMPING OR NON-WEIGHT BEARING CHILD PATHWAY RED FLAGS - In all cases there are specific markers which
FLAGS - In all cases ... splenomegaly, abnormal neurology ... cell disease Rheumatology ... #Limping #NWB #Algorithm ... Pathway #Child #Peds
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Non-autoimmune rheumatologic ... the context of primary ... lower extremity edema ... • May involve PNS ... Erythematosus #Diagnosis #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treatment: • Treat primary ... cause • Correct ... Coagulation #diagnosis #causes ... treatment #management #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Differential Diagnosis Algorithm ... Better call hematology ... up EPO levels Primary ... JAK2 V617F) and MPNs ... #workup #hematology
Primary Dermatological Lesions Primary lesions are physical changes in the skin considered to be caused directly by
considered to be caused ... flat macules of extravascular ... lesions that contain pus ... area of dermal oedema ... #Diagnosis #Dermatology
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