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diagnosis differential intravascular extravascular hemolysis management coagulation dermatology disseminated hemolytic leukemia nonpalpable oncology palpable purpura sjogrens syndrome thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelogenous Leukemia • Primary ... effect following treatment ... Iron deficiency anemia ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
/Quantity: • Primary ... - Hemolytic anemia ... deficiencies - PNH ... Differential #Diagnosis #hematology ... #rheumatology #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • PCH • PNH ... immune-complex hemolytic anemia ... • MAHA (TTP, DIC ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... intravascular coagulation (DIC ... usually IgM) (e.g. primary ... differential #diagnosis #hematology ... #anemia
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
+ Bleeding Treatment ... : • Treat primary ... cause • Correct ... #treatment #management ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... - infiltrates (anemia ... + distinctive primary ... Fibrinolysis & DIC ... #Leukemia #Hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... • Nephrogenic DI ... Hematologic: ... Adenocarcinoma Treatment ... Sjogrens #Syndrome #Rheumatology
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