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diagnosis differential management algorithm oncology rheumatology erythematosus hemolysis intravascular lupus sle systemic treatment cirrhosis classification dermatology extravascular hepatopulmonary leukemia microscopy
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... anemia): ... hemoglobinuria (PNH ... differential #diagnosis #hematology ... #anemia
Peripheral Blood Smear Analysis Hypochromia Megaloblastic Anemia Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS) Microspherocytes: Autoimmune hemolytic anemia Sickled red
Peripheral Blood ... Microangiopathic hemolytic ... #Peripheral #Blood ... Smear #Analysis #hematology ... interpretation #clinical
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • PCH • PNH ... anemia • ... Diagnosis #Algorithm #Causes ... #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Myelodysplastic syndrome ... spherocytosis, Hemolytic ... uremic syndrome ... #differential #hematology
Peripheral blood findings in microangiopathic hemolytic anemia. DIC is a clinical and laboratory diagnosis, not
Peripheral blood ... microangiopathic hemolytic ... anemia. ... DIC is a clinical ... #anemia #Hematology
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Water - Pus ... - Blood • Pleura ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... : - Anemia •
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Drug-associated, PCH, Evans Syndrome ... Liver Disease, PNH ... Defects: Sickle cell anemia ... - Peripheral Blood ... Differential #Diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Myelodysplastic syndrome ... #hematology #secondary
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Viral Infection Clinical ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... #anemia #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Acute hemolysis ... , deficiency anemia ... Diagnosis #Algorithm #hematology
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