15 results
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
of Pregnancy (AFLP ... ) Three syndromes ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... #obstetrics #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... ) - HELLP syndrome ... uremic syndrome ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... defects. 1) HELLP (Hemolysis ... child * Severe cases ... TTPHUS #HELLP #AFLP ... Obstetrics #OBGyn #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Gilbert's syndrome ... • Hemolysis ... diagnosis #algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
necrosis HELLP Syndrome ... (Hemolysis, Elevated ... clinical features: Hemolysis ... of Pregnancy (AFLP ... Disease #Pregnancy #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Bilirubin: RBC (hemolysis ... LDH: Heart, RBC (hemolysis ... • Gilbert's syndrome ... • Hemolysis ... #differential #Hepatology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... Disease, PNH ... Differential #Diagnosis #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... deficiency • Liver ... deficiencies - PNH ... Differential #Diagnosis #hematology
Low Alkaline Phosphatase - Hypophosphatasia 

Is Low Alkaline Phosphatase Of Clinical Importance?

ALP enzyme- Discovered in 1923
Low
synthesized in: liver ... Most cases diagnosed ... membrane into the CNS ... Phosphatase: • Other causes ... Hyophosphatasia #hepatology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Scleromyxedema (CNS ... Amyloidosis (CVS+PNS ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology