19 results
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver ... > 20x normal - Acute ... 2-5x normal - Hemolysis ... #Injury #hepatology ... #LFTs #transaminitis
Causes of Acute Liver Injury - Differential Diagnosis
Hepatocellular - Liver Parenchyma
 • Infectious: Hepatitis C, A,
Causes of Acute ... obstruction, HELLP ... Syndrome, Celiac ... Differential #Diagnosis #Causes ... #hepatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... coagulation (DIC) - HELLP ... syndrome - ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP)
Three syndromes in
Syndrome and Acute ... Pregnancy (AFLP) Three syndromes ... (Hemolysis, Elevated ... child * Severe cases ... AFLP #obstetrics #hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis

 • Infectious: HAV, HCV, HEV, EBV, HSV, CMV
 •
• Congenital: HELLP ... Trauma: Shock liver ... • Autoimmune hepatitis ... Differential #Diagnosis #causes ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... viral hepatitis ... • Gilbert's syndrome ... #differential #Hepatology ... transaminitis #LFTs
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Pregnancy - AFLP, HELLP ... • Alcoholic hepatitis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Acute Liver Injury ... Algorithm Vascular Causes ... of Acute Liver ... • Pregnancy: HELLP ... diagnosis #algorithm #hepatology
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
, no necrosis HELLP ... Syndrome (Hemolysis ... and hemorrhage Acute ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis
Thrombocytopenia and Pregnancy
Three syndromes in the critically ill pregnant woman who presents with coagulation defects.
1) HELLP
Pregnancy Three syndromes ... coagulation defects. 1) HELLP ... (Hemolysis, Elevated ... child * Severe cases ... Obstetrics #OBGyn #Hematology