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diagnosis differential aflp comparison obstetrics pregnancy algorithm hemolysis injury thrombocytopenia ttphus acute anemia common cvid dermatology disease elevated extravascular hypogammaglobulinemia
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
Syndrome and Acute ... (Hemolysis, Elevated ... child * Severe cases ... AFLP #obstetrics #hematology ... #diagnosis #table
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... coagulation (DIC) - HELLP ... syndrome - ... hemoglobinuria (PNH ... differential #diagnosis #hematology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
• Congenital: HELLP ... Trauma: Shock liver ... • Autoimmune hepatitis ... Differential #Diagnosis #causes ... #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Causes of Acute ... biliary obstruction, HELLP ... Syndrome, Celiac ... Differential #Diagnosis #Causes ... Acute #algorithm #hepatology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... (Hemolysis, Elevated ... child * Severe cases ... Obstetrics #OBGyn #Hematology ... Diagnosis #Comparison #Table
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
TTP, HUS, DIC, HELLP ... Drug-associated, PCH, Evans Syndrome ... Defects, Drugs, Liver ... Disease, PNH ... Differential #Diagnosis #hematology
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
, no necrosis HELLP ... Syndrome (Hemolysis ... Disease #Pregnancy #hepatology ... #obstetrics #hepatitis ... diagnosis #icp #HELLP
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Algorithm Vascular Causes ... vein: Budd-chiari syndrome ... • Pregnancy: HELLP ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
DIC/TTP/HUS - Hemolytic ... Kasabach-Merritt syndrome ... deficiency • Liver ... deficiencies - PNH ... Differential #Diagnosis #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disease • Liver ... diseases and hepatitis ... and autoimmune hemolytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
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