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diagnosis differential algorithm anemia dermatology treatment blood classification hemolysis intravascular product rheumatology syndrome transfusion anesthesia anesthesiology antinxp2 antinxp2dm ascites checklist
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... Other: Transfusion reaction ... hemoglobinuria (PNH ... Extravascular #Causes ... differential #diagnosis #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... for workup, including ... blood loss, Acute hemolysis ... Vasculitides, IBD, Celiac disease ... Diagnosis #Algorithm #hematology
Transfusion Reactions - Summary Cheatsheet • Hemolytic Reaction • Febrile Reactions • Transfusion Related Acute Lung
Transfusion Reactions ... Cheatsheet • Hemolytic ... Graft Vs Host Disease ... #diagnosis #management ... #hematology #complications
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Consider sickle cell disease ... platelet decrease - PNH ... Diagnosis #Algorithm #workup ... #hematology #testing
Differential Diagnosis for Hemolytic Anemia Intrinsic Causes: • Enzyme deficiencies ex. G6PD, pyruvate kinase • Hemoglobinopathies
Diagnosis for Hemolytic ... : • Liver disease ... • Transfusion reactions ... udaygulati #Hemolytic ... classification #hematology
Hemolysis - Differential Diagnosis Framework 1) Environment - Fragmentation - MAHA: TTP, HUS, DIC, HELLP
Hemolysis - Differential ... AIHA, Transfusion reactions ... , Drugs, Liver Disease ... , PNH 3) Internal ... Differential #Diagnosis #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... DIC/TTP/HUS - Hemolytic ... deficiencies - PNH ... fever • Drug reactions ... Differential #Diagnosis #hematology
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Causes purpura & ... TRALI): Leading cause ... more likely to cause ... Transfusions #diagnosis #management ... #hematology #reactions
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
hallmark for the disease ... decrease in most cases ... hematuria (without casts ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup ... #Hematology
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