9 results
diagnosis coagulation differential abnormal prolonged ptt anticoagulant apixaban bleeding bruising cascade clot dabigatran dermatology disseminated edoxaban evaluation hemostasis heparin inhibitor
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
Step 1: Is the PT ... K Antagonists, Heparin ... Prolonging the PT ... to identify the cause ... prolonged #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... Fibrinogen: ↓ • PT ... Treat primary cause ... INR < 2.3 - APTT ... treatment #management #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... (e.g. heparin contamination ... thrombin inhibitors, heparin ... intravascularcoagulation (DIC ... #differential #hematology
Prothrombin Time (PT) and Partial Thromboplastin Time (PTT) Prothrombin Time (PT) - Often Elevated in: • Vitamin
Prothrombin Time (PT ... Prothrombin Time (PT ... elevated in: • Heparin ... elevated in: • DIC ... Thromboplastin #laboratory #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... e.g. heparin ... intravascular coagulation (DIC ... #differential #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... deficiencies - PNH ... Purpura Fulminans (DIC ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Acquired: • Heparin ... Warfarin • Acute DIC ... discern these causes ... disease • Acute DIC ... Differential #Diagnosis #Hematology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
thrombin #clot #PT ... #PTT #diagnosis ... #models #hematology ... pathophysiology #anticoagulation ... Rivaroxaban #Edoxaban #heparin
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... Fibrinolysis & DIC ... #Leukemia #Hematology ... #Oncology #Diagnosis
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