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diagnosis pathophysiology cascade differential anticoagulant anticoagulation apixaban arterial clot dabigatran dermatology dic disseminated edoxaban embolism heparin inhibitor intravascular leukemia management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
dysfunction (25%) • Hepatic ... Treat primary cause ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Review of the Coagulation Cascade Traditional Model: • Parallel extrinsic and intrinsic pathways. Contemporary Model: • 4 key
Review of the Coagulation ... Initiation phase caused ... due to vascular injury ... , resulting in coagulation ... #hematology #pathophysiology
The coagulation cascade is shown, separated into different phases with their endogenous and pharmacological inhibitors shown.
The coagulation ... at the site of injury ... PTT #diagnosis #models ... #hematology #pathophysiology ... Rivaroxaban #Edoxaban #heparin
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
vascular disorders, coagulation ... Platelet defects • Coagulation ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... and other causes ... Vasculitis • Injury ... pathophysiology #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... are in the Lymph Nodes ... #Leukemia #Hematology ... #Oncology #Diagnosis
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