9 results
diagnosis differential abnormal coagulation management pt treatment arterial ascites bleeding bruising dic embolism evaluation hemophilia hemostasis intravascular leukemia malignant pathophysiology
How to Evaluate an Abnormal APTT Step 1: Is the PT or APTT Artifactually Prolonged? Step 2: Is
K Antagonists, Heparin ... to identify the cause ... of Prolonged APTT ... #hematology #evaluation ... #mixing #studies
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... e.g. heparin ... Disseminated intravascular ... #Prolonged #Causes ... #differential #hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... thrombin inhibitors, heparin ... hemorrhage • Disseminated ... #Prolonged #Causes ... #differential #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Thrombocytopenia • Prolonged ... Treat primary cause ... bleeding #DIC #Disseminated ... treatment #management #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
is prolonged, but ... corrects with a mixing ... study (aPTT may ... normal in mild cases ... Management #treatment #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Hyperhomocysteinemia - Heparin-induced ... thrombocytopenia - Disseminated ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Perform a PTT mixing ... Acquired: • Heparin ... the PT remains prolonged ... discern these causes ... Differential #Diagnosis #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
mass • Rapidly rising ... -> AML: Blast crises ... count ↑ PLT • ↑ PBS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Common Malignancies That Cause Ascites The most common malignancies causing ascites are ovarian cancer, pancreatic cancer, gastric
Malignancies That Cause ... hypertension or hepatic ... the peritoneal lining ... Differential #Diagnosis #Hepatology ... #oncology
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