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diagnosis differential aptt arterial pt rheumatology thrombosis bleeding bruising clots cryofibrinogenemia dermatology disseminated embolism hemostasis intravascular management nonpalpable palpable pathophysiology
Causes of Arterial and Venous Thrombosis - Differential Diagnosis Framework STRUCTURAL: - PFO: paradoxical emboli - Popliteal
Causes of Arterial ... artery aneurysm: Causes ... intravascular coagulation ... neoplasms - PNH ... Diagnosis #clots #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... Treat primary cause ... 100mg/dL) - Heparin ... #diagnosis #causes ... treatment #management #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... (DIC) c. ... Jcortesizaguirr #Abnormal ... #differential #hematology ... #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
(e.g. heparin contamination ... intravascularcoagulation (DIC ... amyloidosis #Abnormal ... #differential #hematology ... #coagulation
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
marrow disease - DIC ... Defects: • DIC ... deficiencies - PNH ... Cholesterol emboli • Septic ... Differential #Diagnosis #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
Venous Thrombosis ... Hyperhomocysteinemia - Heparin-induced ... intravascular coagulation ... and other causes ... pathophysiology #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
inhibitor of a coagulation ... Acquired: • Heparin ... the PT remains prolonged ... discern these causes ... Differential #Diagnosis #Hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cooled from the normal ... arterial and/or venous ... cryoglobulins • Negative causes ... skin necrosis • DIC ... #hematology
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