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diagnosis differential management anemia leukemia mds myelodysplastic chronic cll fever immunecompromised immunocompromised lymphocytic myelodysplasia pancytopenia syndrome syndromes workup
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Causes of Neutropenia ... Differential Diagnosis Algorithm ... • Toxins • Aplastic ... #Pancytopenia #Neutropenia ... #Causes #Hematology
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... infections from neutropenia ... antibiotics if neutropenic ... • Associated PNH ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... old, ~10,000 new cases ... only curative treatment ... Diagnosis #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Difficulty breathing • Neutropenia ... and petechiae Causes ... anemia Treatment ... #Anemia #oncology ... #hematology #diagnosis
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
Causes of Neutropenia ... the most common cause ... hypertension and/or drug treatment ... white blood cell aplasia ... #hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Cytopenias: • Neutropenia ... Pure red cell aplasia ... microglobulin Treatment ... diagnosis #workup #oncology ... #hematology
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Causes of Fever ... Differential Diagnosis Algorithm ... jirovecii • CNS ... Infection Neutropenia ... #Causes #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... count ↑ PLT • ↑ PBS ... or functional neutropenia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Out Secondary Causes ... • Anemia • Aplastic ... Myeloproliferative Disease • Neutropenia ... Syndromes #diagnosis #hematology ... #oncology
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