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diagnosis management rheumatology syndrome differential activation anthracycline carcinoma cardiology cardiotoxicity cerebritis chemotherapy coagulation dic disseminated erythematosus gastroenterology hcc hemophagocytic hepatocellular
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
neuropathy) • Systemic ... Scleromyxedema (CNS ... +PNS+GI+Endocrine ... Paraproteinemias #Hematology ... Differential #Diagnosis #Oncology
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... of Systemic Lupus ... autoantibodies that will cause ... Erythematosus #SLE #CNS ... #neurology #rheumatology
Systemic Therapy for Hepatocellular Carcinoma - AGA Clinical Practice Guideline First Line Treatment for HCC with Preserved
Systemic Therapy ... First Line Treatment ... Hepatocellular #Carcinoma #Systemic ... #Hepatology #Gastroenterology ... #oncology #Pharmacology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Seen in: • Systemic ... (CNS) dysfunction ... Treatment: • Corticosteroids ... Diagnosis #Management #Hematology ... #Rheumatology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... + Bleeding Treatment ... Treat primary cause ... #treatment #management ... #hematology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Parotid swelling CNS ... (CNS): demyelinating ... • 8%-27% for CNS ... Adenocarcinoma Treatment ... lubricants • Pharmacologic
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... #Leukemia #Hematology ... #Oncology #Diagnosis
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Lymphohistiocytosis (HLH) Treatment ... (depending on CNS ... autoimmune disease, treatment ... Options for severe cases ... #management #hematology
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS What Is IRIS? • A state of hyperinflammatory response that
reconstituted immune system ... pleural effusions, CNS ... infiltrates), organizing PNA ... unintentional weight loss, nausea ... and peripheral edema
Management of Anthracyclines and HER2 Antagonist Cardiotoxicity Anthracyclines cause cardiomyopathy: ✖ Reduction in left ventricular ejection fraction
hypertension, peripheral edema ... ) and initiate treatment ... renin-angiotensin-aldosterone system ... Cardiotoxicity #cardiology #oncology ... #pharmacology #
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