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diagnosis rheumatology lupus hyperkalemia nephrology potassium table treatment antinxp2 antinxp2dm binders binding capsulatum crrt crystalloids dermatology dermatomyositis erythematosus hcq histoplasma
Hydroxychloroquine Serum Measurement in SLE • Terminal elimination half-life = 40 days ([HCQI reflects long-term intake)
Hydroxychloroquine Serum ... Measurement in SLE ... #rheumatology # ... pharmacology #levels ... #lupus #management
Considerations for Crystalloids - 0.9% NS vs LR vs Plasma-Lyte - Causes hyperkalemia? - Safe to
Plasma-Lyte - Causes ... - Causes lactic ... - Serum lactate ... #Crystalloids #pharmacology ... #indications #comparison
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Discontinuation of causal ... Lupusreference #druginduced ... #lupus #sle #comparison ... #table #rheumatology ... #diagnosis #management
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Malignancy (e.g. hematologic ... lower extremity edema ... , and elevated serum ... • May involve PNS ... activation and/or medications
Potassium-Binding Agents to Treat Hyperkalemia Sodium zirconium cyclosilicate (Lokelma): • Mechanism: Preferentially captures K in exchange for
obtain the desired serum ... Side Effects: Edema ... #Hyperkalemia #medications ... #pharmacology # ... table #comparison
Hyperkalemia - Diagnosis and Management - GrepMed Handbook S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Etiology: • Medications ... only if no clear cause ... and Elimination (see ... STOP offending medications ... caution in HTN & edema
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
overlaps with RA, SLE ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... lubricants • Pharmacologic ... #Diagnosis #Management
Renal Replacement Therapy (RRT) - ICU One Pager Summary Indications (AIEOU): • A: Acidosis (usually severe metabolic)
Pager Summary Indications ... valproate, etc); see ... Overload (pulmonary edema ... chosen to match serum ... #Therapy #RRT #managment
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
generalized subcutaneous edema ... Pts have more ... Muscle atrophy may cause ... levels of: • Serum ... Dermatomyositis #diagnosis #management
IDSA Recommendations for Preventing and Treating Histoplasma Capsulatum Infections in HIV-AIDS Indications for Initiating Primary Prophylaxis: •
histoplasmosis (>10 cases ... interactions with ARV (see ... and itraconazole serum ... Prevention #Treatment #management ... infections #HIVAIDS #pharmacology
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