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diagnosis treatment differential extravascular hemolysis hemophagocytic hlh lymphohistiocytosis anemia antinxp2 antinxp2dm cardiology chf clinical coagulation criticalcare dermatology dermatomyositis dic disseminated
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... Differential Diagnosis Algorithm ... Cold AIHA • Alloimmune ... • PCH • PNH ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Causes Intravascular ... hemoglobinuria (PNH ... idiopathic) - Autoimmune ... #Causes #differential ... #diagnosis #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Disseminated Intravascular ... Treat primary cause ... #Disseminated #Intravascular ... #treatment #management ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
lymphoma (DLBCL, intravascular ... solid cancers • Autoimmune ... Drugs, Unknown cause ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
be any age) Autoimmune ... Hypocomplementemia • Can cause ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
It is important to recognize Acute Decompensated Heart Failure (ADHF) as more than just simply a
JVD, Orthopnea/PND ... the determined cause ... #differential #algorithm ... #management #cardiology ... #treatment #table
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... with infection or autoimmune ... Options for severe cases ... HLH #Treatment #management ... #hematology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
generalized subcutaneous edema ... Pts have more ... Muscle atrophy may cause ... Dermatomyositis #diagnosis #management ... #rheumatology #
TAFRO TAFRO syndrome was first described in 2010, standing for: - Thrombocytopenia - Anasarca - Fever - Reticulin fibrosis - Organomegaly TAFRO syndrome
mesothelioma, etc - Autoimmune ... cell lymphoma - Intravascular ... histopathologic changes in LNs ... TAFRO #diagnosis #management ... #rheumatology #
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