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diagnosis neurology rheumatology treatment differential oncology antinxp2 antinxp2dm cerebritis classification clinical coagulation crypto cryptococcal dermatomyositis dic disseminated erythematosus essential et
CNS Ring-Enhancing Lesions - Immunocompromised vs Immunocompetent Multiple Ring-Enhancing Lesions: • Toxoplasmosis (CD4 < 100) • Other
CNS Ring-Enhancing ... Compatible syndrome + MRI ... + toxo IgG • CNS ... 30% present w/ CNS ... @AnnKumfer #CNS
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... thrombosis and/or blood-brain ... Erythematosus #SLE #CNS ... cerebritis #diagnosis #management
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thromboembolism (7%) • CNS ... Treat primary cause ... Coagulation #diagnosis #causes ... #treatment #management ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
involvement • 30%: CNS ... -> AML: Blast crises ... leukostasis syndrome: CNS ... manifestations, hypoxia, CXR ... #Leukemia #Hematology
Transverse Myelitis Overview Focal inflammatory disorder of the spinal cord resulting in rapid onset of weakness, sensory
that results in CNS ... • Infectious causes ... ruled out • Brain ... brain and/or optic ... Myelitis #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rule out other causes ... - MRI: inflammation ... #diagnosis #management ... #Dermatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
(depending on CNS ... steroids • In mild cases ... Options for severe cases ... HLH #Treatment #management ... #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
of about three cases ... Serum Copper • Chest ... cycles without XR ... classification #hematology ... #oncology #management
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... MI, stroke, DVT/ ... Thrombocythemia #ET #hematology ... #diagnosis #management ... #hematology
Cryptococcal meningitis on T2 MRI 30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
meningitis on T2 MRI ... low glucose) CNS ... Nausea & vomiting ... #Brain #clinical ... #radiology
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