9 results
Recurrent / Breakthrough DVT During Anticoagulation

Subtherapeutic Anticoagulation
Hypercoagulable State 
 - Antithrombin deficiency 
 - Hypercoagulability ot
Behcet's disease - APLS ... - MPN/PNH ... Structural - Pelvic masses ... Recurrent #DVT #VTE ... anticoagulation #hematology
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework

VENOUS THROMBOSIS

 • Acquired Risk Factors:
	- >48 hours
Hyperviscosity, TTP, APLS ... Antiphospholipid antibodies (APLS ... coagulation and other causes ... - COVID-19 - PNH ... pathophysiology #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Hemolytic anemia ... - APLS • Acute ... Differential #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
Cardiovascular Causes ... - Water - Pus ... Guillain Barre - ALS ... Transverse myelitis • Hematology ... : - Anemia
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... autoantibodies that will cause ... (for secondary APS ... #neurology #rheumatology ... cerebritis #diagnosis #management
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... hemoglobinuria (PNH ... usually IgG) (e.g. lupus ... differential #diagnosis #hematology ... #anemia
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
nervous system (CNS ... SJIA], systemic lupus ... with leukopenia, anemia ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Antiphospholipid Syndrome (APLS) Testing - Hypercoagulable Workup Algorithm
INDICATIONS FOR TESTING:
 • Vascular thrombosis
Antiphospholipid Syndrome (APLS ... clinical episodes of arterial ... maternal chromosomal causes ... excluded Testing: • Lupus ... Algorithm #diagnosis #hematology
Endocarditis Summary

Who?
Infectious:
• Pre-existing valvular disease
• Prosthetic valve
• Congenital heart disease
• IV substance use
• IV catheter
• Recent
Hypercoagulable (APLAS ... Septic Emboli Cause ... Leukocytosis, anemia ... Endocarditis #diagnosis #management ... #cardiology