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diagnosis gammopathy syndrome algorithm disease multiplemyeloma oncology treatment agglutinin anemia antinxp2 antinxp2dm biopsy capillary chronic clarksons classification cll coagulation cold
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS) Mayo Clinic Risk Stratification Model. CBC,
significance (MGUS ... ) Mayo Clinic Risk ... #MGUS #Followup ... algorithm #diagnosis #management ... #hematology #multiplemyeloma
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
patients with monoclonal ... , low-risk MGUS ... whom there are no clinical ... algorithm #diagnosis #management ... #hematology #multiplemyeloma
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS) Fracture, Osteoporosis - Increased osteoclast activity and bone resorption
Significance (MGUS ... rituximab (in clinical ... thromboprophylaxis in high-risk ... situations #MGUS ... Complications #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... IgM) • Blood smear ... disease (younger pts ... significance (MGUS ... hemolytic #anemia #hematology
Chronic Lymphocytic Leukemia (CLL) - Summary Overview: • Most common leukemia in adults • Disorder of
• Peripheral smear ... immunophenotype Clinical ... chemotherapy for low-risk ... fludarabine) 3) Monoclonal ... Leukemia #oncology #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
organ damage Clinical ... • Peripheral smear ... Treat primary cause ... #treatment #management ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
increased infection risk ... to 8 years Clinical ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... Rule out other causes ... SAPHO #Syndrome #Rheumatology ... #diagnosis #management ... #Dermatology
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Relapsing-remitting course +++ Clinical ... Monoclonal gammopathy ... Prevention of at-risk ... syndrome #diagnosis #management ... timeline #treatment #rheumatology
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... salivary ducts Clinical ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
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