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management differential treatment hemeonc rash workup algorithm anemia disease leukemia monoclonal myelodysplastic cellulitis chronic classification cll cutaneous dermatomyositis erythematosus hemolytic
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
Myelodysplastic Syndrome ... old, ~10,000 new cases ... • Risks: infection ... Management #treatment #hematology ... #oncology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Differential Diagnosis ... purple, hemorrhagic skin ... deficiencies - PNH ... #hematology #rheumatology ... #nonpalpable #dermatology
Cutaneous manifestations associated with myelodysplastic syndrome • Myeloid hemopathy with the most frequent skin lesions (20%)
myelodysplastic syndrome ... most frequent skin ... #differential #diagnosis ... #dermatology #oncology ... #clinical #skin
Dyspnea - Differential Diagnosis Framework Cardiovascular Causes of Dyspnea: • Myocardium: - Heart failure - CAD/ACS - Valvulopathy • Electrical: -
- Differential Diagnosis ... - Water - Pus ... Hepatopulmonary syndrome ... Transverse myelitis • Hematology ... #differential #diagnosis
Venous Thrombosis vs Arterial Thrombosis - Differential Diagnosis Framework VENOUS THROMBOSIS • Acquired Risk Factors: - >48 hours
• Acquired Risk ... Testosterone - Coumadin skin ... • Nephrotic Syndrome ... coagulation and other causes ... pathophysiology #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
GPA causes disease ... Rarely dominate the clinical ... • Goodpasture syndrome ... Polyangiitis #GPA #dermatology ... #rheumatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
Alpha & Mu) Skin ... Amyloidosis (CVS+PNS ... Paraproteinemias #Hematology ... #Differential #Diagnosis ... #Oncology
Nikolsky's Sign in Toxic Epidermal Necrolysis (TEN) Nikolsky's sign is a clinical dermatological sign which is present
Nikolsky's sign is a clinical ... Stevens-Johnson Syndrome ... syndrome, caused ... differentiating between the diagnosis ... Nikolskys #Sign #TEN #Dermatology
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 Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... ) - HELLP syndrome ... hemoglobinuria (PNH ... #hematology #anemia
SAPHO Syndrome Summary What? SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
blisters containing pus ... : • A clinical ... out other causes ... #Rheumatology # ... #Dermatology
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